Focus areas

Center for Heart Failure Research Establish Focus Areas

In an effort to further promote the highly successful interaction between research groups within the Center for Heart Failure Research,
several Focus Areas will be launched throughout 2018.


Workshops

The main meeting place for each Focus Area will be annual Workshops.
Make sure to subscribe to our newsletter for more information about these and more Focus Areas throughout 2018.

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Please note the following Workshops, and stay tuned for more throughout the year.

Focus Areas Index:

Innate immunity in cardiovascular disease
Multimodality imaging in cardiac disease
Dyssynchrony in heart failure
Cardiac arrhythmias and electrophysiology
Cardio-oncology
Cardiac mitochondria in health and disease
Cardiomyocyte mechanisms of heart failure
Cardiomyopathies
Diastolic function in cardiac disease

The Focus Areas will be dedicated to specific topics of interest to several groups in the Center, and facilitate exchange of ideas, common projects and collaboration with international partners.


Innate immunity in cardiovascular disease

Ragnhild Helseth
Ragnhild Helseth


Coronary heart disease is today regarded as a partly inflammatory driven process, in which components of both the innate and adaptive immune system influence coronary plaque progression. Currently, no treatment option in coronary heart disease targets immune activation spesifically.

We aim to focus on how the innate immune system affects ischemic coronary artery disease and other cardiovascular diseases. By serving as a plattform for knowledge sharing, ideas and cooperation across research affiliations, our goal is to achieve enhanced understanding of innate immunity in cardiovascular disease so that improved prevention and treatment of such diseases eventually can be developed.

Focus area: Innate immunity in cardiovascular disease
Focus area leader: Ragnhild Helseth, resident in internal medicine and postdoc, Department of emergency medicine and Center for clinical heart disease, Department of Cardiology, Oslo University Hospital Ullevål
Affiliated CHFR group: professor dr. philos Ingebjørg Seljeflot,Department of Cardiology, Oslo University Hospital Ullevål

Workshop: Neutrophil and inflammasome related activation in atherosclerotic disease
Date: Thursday April 5th, 1130 – 1600

Multimodality imaging in cardiac disease

Nina Eide Hasselberg
Nina Eide Hasselberg


Cardiac imaging is a field in constant growth in clinical cardiology. This CHFR group is aiming to explore the potentials of cardiac imaging to assess myocardial function as a tool to monitor disease progression and prognosis in heart failure secondary to both cardiomyopathies and valvular disease. Imaging techniques to predict severe outcomes and the value of imaging to differentiate the normal heart from early changes in cardiomyopathies are central fields of interest. Echocardiography is the most studied and clinically used modality, but we also aspire to study the value of cardiac MRI (CMR) and cardiac CT in these matters.

Focus area: Multimodality imaging in cardiac disease
Focus area leader: Nina Eide Hasselberg, Dept of Cardiology and Center for Cardiological Innovation, Oslo University Hospital Rikshospitalet
Affiliated CHFR group: Professor Thor Edvardsen, Dept of Cardiology and Center for Cardiological Innovation, Oslo University Hospital Rikshospitalet, and University of Oslo

Workshop: Echocardiographic assessment of myocardial function in athletes and cardiomyopathy
Date: Tuesday April 10th 2018, 11 am – 3 pm

Dyssynchrony in Heart Failure

Person no photo availiable 400x550
John Aalen


The main topic of interest for the focus group is dyssynchrony induced by left bundle branch block or right ventricular pacing and the consequences for the failing heart. Increased knowledge of the relationship between electrical and mechanical dyssynchrony and how it affects the heart during different conditions (ischemia, load etc.) is likely to be of importance for patient management. In particular, we will focus on the use of various methods to select patients and evaluate response to cardiac resynchronization therapy.

Focus area:Dyssynchrony in Heart Failure
Focus area leader: John Aalen, Institute for Surgical Research, Center for Cardiological Innovation and department of Cardiology, Oslo University Hospital Rikshospitalet
Affiliated CHFR group: professor Otto A. Smiseth, Institute for Surgical Research, Center for Cardiological Innovation and department of Cardiology, Oslo University Hospital Rikshospitalet

Cardiac arrhythmias and electrophysiology

Mathis Korseberg Stokke
Mathis Korseberg Stokke


This focus area will bring together basic scientists, clinical researchers and clinicians with a special interest in cardiac arrhythmias and electrophysiology. The aim is to elucidate the fundamental mechanisms for arrhythmias in an effort to diagnose, predict, prevent and treat patients suffering for arrhythmias and sudden cardiac death. The scope will range from biophysical properties of ion channels to clinical observations and interventions.

Focus area: Cardiac arrhythmias and electrophysiology
Focus area leader: Mathis Korseberg Stokke, Department of Cardiology, Oslo University Hospital Rikshospitalet
Affiliated CHFR group:professor Thor Edvardsen, Department of Cardiology, Oslo University Hospital Rikshospitalet

Cardio-oncology

Person no photo availiable 400x550
Geeta Gulati


The field of cardio-oncology has gained a lot of interest both clinically and in research as long-term survival of cancer patients have become common. High quality studies are necessary to evaluate the role of preventive cardio-protective medication during cancer therapy. The purpose of this group is to create awareness of the research in cardio-oncology, and highlight the importance of randomized placebo controlled trials and the use of cardiac imaging.

Focus area: Cardio-oncology
Focus area leader: Geeta Gulati, Department of Cardiology, Akershus University Hospital
Affiliated CHFR group: professor Torbjørn Omland, Department of Internal Medicine, Akershus University Hospital

Cardiac mitochondria in health and disease

May-Kristin Torp med ramme
May-Kristin Torp


The mitochondrion is the power house of the cell creating ATP through oxidative phosphorylation. The heart is a particularly mitochondria rich organ due its large energy demand. In various diseased states, the mitochondrion can turn from good to bad, causing damage through production of oxygen radicals, by inducing apoptosis and also activate inflammatory responses. The focus area “Cardiac mitochondria in health and disease” work to reduce damage caused by mitochondria after myocardial infarction and to reduce development of heart failure due to ischemic heart disease.

Focus area: Cardiac mitochondria in health and disease
Focus area leader: May-Kristin Torp, Heart Physiology group, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo
Affiliated CHFR group: professor Kåre-Olav Stensløkken, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo

Workshop: Role of mitochondria in cardiac disease
04.05.2018, 09:00-13:00

Cardiomyocytes Mechanisms of Heart Failure

Xin Shen 5x7 B
Xin Shen


Over the last years, our research has shown that weakened contraction of the heart during heart failure (HF) can be traced to reduced contraction of individual cardiac muscle cells (cardiomyocytes), and that this deficit results principally from disruption of sub-cellular structures called “dyads”. The goal of this focus area is to establish a forum in which researchers are able to share their latest discoveries on underlying cardiomyocyte mechanisms contributing to HF. Moreover, we aim to adopt an integrative approach by incorporating other relevant fields of cardiovascular research through collaborations in order to address this debilitating disease.

Focus area: Cardiomyocytes Mechanisms of Heart Failure
Focus area leader: Xin Shen, IEMR
Affiliated CHFR group: professor William E. Louch, Institute for Experimental Medical Research, Oslo University Hospital Ullevål

Cardiomyopathies

Ida Gjervold Lunde, CHFR
Ida Gjervold Lunde


Cardiomyopathies will be one focus area of the CHFR. Cardiomyopathy refers to diseases of the heart muscle, and the main types are dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy and arrhythmogenic cardiomyopathy. Basic scientists and clinician-scientists in the field will come together to discuss key scientific questions and to collaborate on research projects within this field.

Focus area: Cardiomyopathies
Focus area leader: Ida Gjervold Lunde, PhD FESC, Institute for Experimental Medical Research (IEMR), Oslo University Hospital (OUH) & University of Oslo (UoO).
Affiliated CHFR group: professor Geir Christensen, Institute for Experimental Medical Research, Oslo University Hospital Ullevål

Diastolic function in cardiac disease

Emil K. S. Espe
Emil Espe


Diastolic dysfunction (DD) affects many cardiac patients and is one of the greatest challenges in cardiovascular medicine today. The new focus area «Diastolic function in cardiac disease» aims to be a platform for researchers on all aspects of DD; 1) basal mechanisms, 2) imaging and diagnostics and 3) clinical research. One of the key goals of the focus area is to bring young and experienced scientists closer together. In this, the annual workshop plays an important role.

Focus area: Diastolic function in cardiac disease
Focus area leader: Emil Espe, Institute for Experimental Medical Research, UiO/OUS, IEMR
Affiliated CHFR group: professor Ivar Sjaastad, Institute for Experimental Medical Research, Oslo University Hospital Ullevål

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