Phone 90676276     Email k.h.hortemomedisin.uio.no

Kristin Halvorsen Hortemo, PhD student

Kristin Halvorsen Hortemo

Department Institute for Experimental Medical Research, Oslo University Hospital Ullevaal

Current research focus

Skeletal muscle fatigue in health and disease.

Main hypothesis:
Posttranscriptional modifications of proteins participating in the contraction-relaxation cycle is different in isometric and isotonic exercise, and alterations in these modifications contribute to the skeletal dysfunction seen in CHF.

Specific aims/subgoals:

  • Identify the fatigue development in normal rats and in rats with post-infarct heart failure during in situ shortening contractions
  • In normal rats, identify the phosphorylation pattern of regulatory proteins important for contraction in isometric versus isotonic exercise
  • Investigate alterations in phoshorylation pattern in rats with post-infarct heart failure
  • Investigate alterations in O-linked-Glycosylation after shortening contractions in normal rats and rats with post-infarct heart failure
  • Integrative understanding og skeletal muscle fatigue including metabolite alterations and calcium handling

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