Department of Pharmacology, University of Oslo

Current research focus

Study the effects of natriuretic peptides on contractility and cGMP compartmentation in failing myocardium.

Research projects

Project manager

• Regulation of serotonin receptor expression in normal and failing hearts
• Signalling transduction and regulation of 5-HT₄-induced contractile effects in failing myocardium
• Signalling mechanisms for the effects of natriuretic peptides on contractility in failing myocardium
• Cyclic GMP compartmentation in failing myocardium

Supervisor

• Animal modetl for studiing heart failure with preserved ejection fraction (HFpEF) and Signalling mechanisms for the effects of natriuretic peptides (CNP) on contractility in HFpEF

Collaborator

• Compartmentalized receptor-mediated signaling through cAMP and cGMP in cardiomyocytes
• Crosstalk of cGMP on cAMP signalling systems in cardiomyocytes. A key to modifications of cAMP-dependent receptor functions in failing myocardium?
• Regulation of myocardial cGMP by PDE subtypes.
• A comparison between the receptor signalling mechanisms coupled to 5-HT4 serotonin receptors and to beta-adrenoceptors in failing myocardium.
• cGMPs influence on cAMP