Håvard Attramadal group - Molecular Cardiology

Group strategy

The major focus of our research group is:

  1. to uncover mechanisms that control the responsiveness of the heart to neurotransmitters, neurohormones, and autocrine/paracrine factors involved in regulation of cardiac growth and contractility in health and disease.
  2. to unravel the mediators and molecular mechanisms of pathologic myocardial hypertrophy in chronic pressure overload.
  3. to elucidate autocrine/paracrine factors, extracelllular matrix interactions, and signaling mechanisms promoting or inhibiting progression of heart failure.
  4. to unravel novel mediators and mechanisms of cardioprotection ischemia/reperfusion injury of the heart.

The group is currently investigating the role of matricellular CCN proteins in normal physiologic regulation of the heart, the role of CCN proteins in regulation of tolerance towards ischemia/reperfusion injury and in the pathophysiology of heart failure. Another major ongoing project is aimed at deciphering the physiologic roles of four different cardiac G protein-coupled receptor kinases (GRK2, GRK3, GRK5, and GRK6), i.e. enzymes that catalyze phosphorylation and desensitization of G protein-coupled receptors, and to resolving the putative involvement of any of these kinases in pathologic hypertrophy and heart failure. The purpose of these investigations is to provide new knowledge on the molecular mechanisms of pathologic myocardial remodelling and heart failure in order to identify targets for development of novel pharmacologic treatment modalities.

Head of group

Håvard Attramadal

 

Håvard Attramadal

Professor, MD, PhD

Group members

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