Institute for Experimental Medical Research, Oslo University Hospital Ullevaal

Current research focus

1. Basic cellular electrophysiology
2. Basic electrophysiology in channelopathies and cardiomyopathies
3. Translational projects on channelopathies and cardiomyopathies

Research projects

Project manager

• Determining factors for triggered arrhythmias
• L-type Ca2+ current inhibition for prevention of triggered arrhythmias
• Exercise training as anti-arrhythmic therapy in heart failure

Supervisor

• Effects of Individualized Exercise Training in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
• Exercise training prevents ventricular tachycardia in CPVT 1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release
• Causal link between contractile dysfunction and risk of arrhythmias in post infarction rats
• Can exercise training prevent ventricular arrhythmias in heart failure?

Collaborator

• Crosstalk between transport proteins that control intracellular sodium in cardiomyoctyes
• IP₃ signalling and Ca²⁺-wave development in ventricular cardiomyocytes
• Spatial homogeneity of cardiomyocyte Ca²⁺ handling and sarcomeric function
• Optimization of gene deletion protocols in mouse models utilizing Mer-Cre-Mer (MCM) technology