European Heart Journal

Hot Topics: Young patients with lamin A/C mutations have high cardiac penetrance and frequent need for heart transplantation

Lamin A/C genotype-positive family members had a 9% annual incidence of a newly documented cardiac phenotype and 61% of cardiac penetrance during 4.4 years of follow-up. Heart transplantation was performed in 19% lamin A/C patients during 7.8 years of follow-up.

Read more in European Heart Journal

Int J Cardiol 2017_420

Hot Topics: Heart rate prediction of outcome in HF following MI

In patients with reduced systolic function and/or HF post-MI, higher heart rate predicts increased major cardiovascular events during the first year following MI in patients without AF. This association is markedly attenuated in subjects with AF.

Read more in International Journal of Cardiology 2017; 249: 274-281.

Journal of the American College of Cardiology 70

Hot Topics: Due to geometric confounders, strain better reflects systolic function in patients with preserved EF

Using an analytical equation showing the relationship between EF and global longitudinal and circumferential strain, wall thickness, and short-axis diameter, it was found that reduced deformation despite preserved EF can be explained through geometric factors.

Read more in Journal of the American College of Cardiology, Volume 70, Issue 8

Journal of the American College of Cardiology

Hot Topics: Echocardiographic assessment of LV filling pressure is feasible and accurate

In a multicenter study of 450 patients using invasively measured LV pressure as the gold standard, echocardiography had an accuracy of 87% of identifying patients with elevated LV filling pressure.

Read more in Journal of the American College of Cardiology, Volume 69, Issue 15


Hot Topics: Beta-blockers improve EF and prognosis for patients with HFrEF and HFmrEF but not with HFpEF

A meta-analysis of 11 trials demonstrated that beta-blockers reduce all-cause and cardiovascular mortality and increase EF in patients in sinus rhythm with EF < 50%. For patients in atrial fibrillation, beta-blockers increased EF when < 50% at baseline, but did not improve prognosis.

Read more in European Heart Journal

Scientific Reports 7

Hot Topics: Circulating levels of CCN2 in the acute phase of STEMI are not associated with final infarct size, LV function or new clinical events

Although a possible cardioprotective role of CCN2/CTGF following myocardial infarction has been suggested, no significant associations between levels of CCN2 and infarct size, LV remodelling and function and new clinical events including mortality were found.

Read more in Scientific Reports 7, Article number: 11945 (2017)

Cell Reports, Volume 18, Issue 1

Hot Topics: NEIL3-dependent regulation of cardiac fibroblast proliferation prevents myocardial rupture

Neil3-/- mice show increased mortality after myocardial infarction caused by myocardial rupture. Neil3-/- ruptured hearts show increased proliferation of fibroblasts and myofibroblasts.

Read more in Cell Reports, Volume 18, Issue 1

Journal of Biological Chemistry 2016

Hot Topics: Protein phosphatase 1c associated with the cardiac sodium calcium exchanger 1 (NCX1) regulates its activity by dephosphorylating serine 68-phosphorylated phospholemman

NCX1, an important regulator of intracellular Ca2+ homeostasis, is a substrate-specifying PP1c-targeting protein. Using a variety of molecular techniques, this study demonstrates that cardiac NCX1 facilitating its own regulation by mediating dephosphorylation of pSer-68-phospholemman.

Read more in Journal of Biological Chemistry

European Heart Journal 2016

Hot Topics: Tocilizumab attenuated the inflammatory response and primarily PCI-related TnT release in NSTEMI patients

In a double-blind, placebo-controlled trial including 117 patients with NSTEMI, the IL-6 receptor antagonist tocilizumab administered as a single dose prior to coronary angiography reduced the levels of CRP and troponin-T.

Read more in European Heart Journal

Resuscitation 2016

Hot Topics: NT-proBNP levels improve risk assessment for poor outcome in patients with out-of-hospital cardiac arrest

NT-proBNP levels measured 24 hrs after out-of-hospital cardiac arrest predicted mortality and poor neurological outcome after one year on top of established risk indices.

Read more in Resuscitation

European Journal of Heart Failure cover

Hot Topics: Serum uric acid is associated with mortality and heart failure hospitalizations in patients with complicated myocardial infarction

Elevated serum uric acid levels are associated with poor outcomes in patients after myocardial infarction complicated by reduced left ventricular function, heart failure, or both, and quantification of serum uric acid could improve risk stratification of patients with complicated myocardial infarction.

Read more in European Journal of Heart Failure

Journal of Cardiac Failure cover

Hot Topics: Epicardial adipose tissue may be a source of increased circulatory levels of fatty acids and inflammatory and metabolic mediators in systolic heart failure

Higher expression of fatty acids and mRNAs encoding different inflammatory and metabolic mediators was found in epicardial adipose tissue from patients with systolic heart failure, and palmitoleic acid levels were correlated with parameters of cardiac remodeling.

Read more in Journal of Cardiac Failure

Cardiovascular Interventions. cover

Hot Topics: Initial ECG findings are not reliable in detecting patients with an indication for immediate coronary angiography after cardiac arrest

An analysis of 210 resuscitated patients admitted after out-of-hospital cardiac arrest demonstrated that even in the absence of ECG changes indicating myocardial ischemia, an acute culprit lesion may be present and patients may benefit from emergent revascularization

Read more in Circulation: Cardiovascular Interventions

Cardiovascular Research 2015

Hot Topics: Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart

Syndecan-4 exerts a dual role in collagen cross-linking, one involving its cytosolic domain and NFAT signalling leading to collagen, osteopontin, and lysyl oxidase induction in cardiac fibroblasts; the other involving the extracellular domain promoting lysyl oxidase-dependent cross-linking.
Read more in Cardiovascular Research

JACC: Cardiovascular Imaging 2015

Hot Topics: Subjects with long QT syndrome have reduced cardiac function

Subjects with LQTS have reduction in systolic function (reduced global longitudinal strain, increased contraction duration and more dispersed contractions) and diastolic function (lower e' and increased left atrial volume index ) with differences in myocardial function between subjects with LQT1 and LQT2.

Read more in JACC: Cardiovascular Imaging

Journal of Internal Medicine 2015

Hot Topics: Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

Trimethylamine-N-oxide, a microbiota-dependent metabolite from dietary phosphatidylcholine and carnitine, is elevated in patients with chronic HF with the highest levels in patients with NYHA classes III and IV and is associated with reduced transplant-free survival.
Read more in Journal of Internal Medicine

International Journal of Cardiology-cov150h

Hot Topics: Soluble ST2 reflects hemodynamic stress in non-ischemic heart failure

In 102 patients with idiopathic dilated cardiomyopathy, soluble ST2 levels were elevated in patients with severe symptoms, but did not vary with etiology, viral presence or the amount of myocardial fibrosis, indicating that soluble ST2 reflects hemodynamic stress rather than pathogenic processes in the myocardium.

Read more in International Journal of Cardiology

Circ Heart Fail 2015 Jan

Hot Topics: Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy

Four 4 weeks of treatment with LCZ696 after myocardial infarction in rats resulted in lower cardiac weights and markedly reduced fibrosis as well as lower LV end-diastolic diameter and higher LV ejection fraction, diastolic wall strain, and circular strain.

Read more in Circulation: Heart Failure

Journal of the American College of Cardiology-cov150h

Hot Topics: Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling

Secretoneurin provided incremental prognostic information to established risk indices in acute heart failure and ventricular arrhythmia-induced cardiac arrest. High secretoneurin levels may be a compensatory protective mechanism in cardiovascular disease as secretoneurin improves Ca2+ handling by CaMKIIδ inhibition.

Read more in JACC (Journal of the American College of Cardiology)

European Journal of Heart Failure,  Volume 16, Issue 12

Hot Topics: Exercise may aggravate and accelerate myocardial dysfunction in ARVC

Biventricular function was reduced in athletes compared with non-athletes in ARVC patients and in mutation-positive family members. The amount and intensity of exercise activity was associated with impaired LV and RV function.

Read more in European Journal of Heart Failure

Critical Care Medicine

Hot Topics: Bradycardia during therapeutic hypothermia is associated with good neurologic outcome in comatose survivors of out-of-hospital cardiac arrest

Survival rate with good neurologic outcome at hospital discharge after out-of-hospital cardiac arrest was 60% in patients with heart rate ≤ 60 beats/min during therapeutic hypothermia vs. 37% in patients with heart rate > 60 beats/min.

Read more in Critical Care Medicine

Journal of Biological Chemistry

Hot Topics: Identification of a novel calpain cleavage site in the Na+-Ca2+ exchanger 1 (NCX1)

NCX1 and the Ca2+-activated protease calpain were up-regulated in aortic stenosis patients and rats with heart failure and co-localized in cardiomyocytes. A novel calpain cleavage site in NCX1 was found leading to inhibited NCX1 activity which might be beneficial in pathophysiological conditions where increased NCX1 activity contributes to cardiac dysfunction.

Read more in Journal of Biological Chemistry

Stem Cells 2014;32, 2123-2134

Hot Topics: Remote transplantation of mesenchymal stem cells protects the heart against ischemia-reperfusion injury

Subcutaneous transplantation in the interscapular region of mouse adipose-derived mesenchymal stem cells resulted in smaller infarcts and improved cardiac function after ischemia-reperfusion ex vivo and improved LV function when transplanted in vivo after myocardial infarction

Read more in STEM CELLS, Volume 32, Issue 8

. Am J Transplant 2014;14,1828-1838

Hot Topics: Everolimus-based immunosuppression with early elimination of cyclosporine markedly improved renal function after heart transplantation

Everolimus-based immunosuppression with early elimination of cyclosporine after heart transplantation markedly increased GFR, attenuated the increase in coronary intimal thickness and reduced the incidence of cardiac allograft vasculopathy.

Read more in American Journal of Transplantation 2014;14,1828-1838.

Eur Heart J. 2014 Sep 1.

Hot Topics: TRO40303 did not show any effect limiting reperfusion injury in STEMI

The putative cardioprotective compound TRO40303 did not reduce infarct size or increase myocardial salvage index or LVEF in patients undergoing revascularization for STEMI.

Read more in European Heart Journal, 2014 Sep 1.

J Am Heart Assoc 2014;3

Hot Topics: No effect of ischemic postconditioning in patients with myocardial infarction

In contrast to previous smaller trials, no significant effects of ischemic postconditioning on infarct size or secondary study outcomes were found in patients with acute myocardial infarction.

Read more in Journal of the American Heart Association (JAHA)


Hot Topics: Increased levels of circulating miR-210 in aortic stenosis

Circulating miR-210 levels are increased in patients with aortic stenosis and provide independent prognostic information to established risk indices, supporting the potential of micro-RNAs as novel CV biomarkers.

Read more in PLOS ONE by the Public Library of Science

Eur J Heart Fail 2014

Hot Topics: Interleukin-8 is associated with adverse outcome in chronic heart failure

In 1464 patients with chronic ischaemic systolic heart failure (CORONA study), IL-8 was a significant predictor of nearly all endpoints including all-cause mortality and CV hospitalization.

Read more in European Journal of Heart Failure

Br J Pharmacol. 2014 Feb 18

Hot Topics:The inotropic effect of levosimendan is mediated by PDE3-inhibition

Studies on ventricular strips from explanted failing human hearts indicate that the PDE3-inhibitory property of levosimendan is sufficient to account for its inotropic effect, leaving a minor if any effect to a calcium-sensitising component.

Read more in British Journal of Pharmacology

Eur Heart J. February 1, 2014  35.gif

Hot Topics: Calcium channel blockers improve exercise capacity compared with beta-blockers in patients with permanent atrial fibrillation

Rate-reducing treatment with diltiazem or verapamil preserved exercise capacity and reduced levels of NT-proBNP, whereas metoprolol or carvedilol reduced the exercise capacity and increased levels of NT-proBNP in patients with permanent atrial fibrillation.

Read more in European Heart Journal

British Journal of Pharmacology

Hot Topics: SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium

CNP-induced phospholamban and troponin-T phosphorylation by PKG in concert mediate both a predictable lusitropic response as well as the less expected negative inotropic response in failing hearts and the presence of SERCA2 activity is necessary for these effects.

Read more in British Journal of Pharmacology

Circulation: Heart Failure 2

Hot Topics: Elevated hs-troponin-T levels provide strong and independent prognostic information in older patients with chronic ischemic HF

Hs-troponin-T in 1245 patients ≥60 years with ischemic systolic HF in the CORONA study was associated with all end points.

Read more in Circulation: Heart Failure

JACC - Cardiovascular Imaging

Hot Topics: Strain echocardiography improves risk prediction of ventricular arrhythmias after myocardial infarction

Haugaa KH, Grenne BL, Eek CH, Ersbøll M, Valeur N, Svendsen JH, Florian A, Sjøli B, Brunvand H, Køber L, Voigt JU, Desmet W, Smiseth OA, Edvardsen T.

JACC: Cardiovascular Imaging
Volume 6, Issue 8, August 2013, Pages 841–850
doi: 10.1016

Click and read

Cardiovasc Res. 2013, 3_cover

Hot Topics: The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury

Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, Fitzgerald KA, Lien E, Valen G, Espevik T, Aukrust P, Yndestad A.

Cardiovasc Res. 2013 Jul 1;99(1):164-74.
doi: 10.1093/cvr/cvt091. Epub 2013 Apr 10.

Click and read

Plos One Twitter 175x175

Hot Topics: The co-existence of the IL-18+183 A/G and MMP-9 -1562 C/T polymorphisms is associated with clinical events in CAD patients.

The IL-18+183 G-allele was associated with 35% risk reduction whereas the IL-18+183 AA/MMP-9 -1562 CT/TT combined genotypes were associated with a 1.87-fold increase in risk of composite endpoints in stable CAD patients

Read more in Public Library of Science (PLOS)

PLOS ONE is an international, peer-reviewed, open-access, online publication.


Hot Topics: Myocardial salvage is reduced in primary PCI-treated STEMI patients with microvascular obstruction

The presence of microvascular obstruction demonstrated by cardiac MR in STEMI patients is associated with large infarct size, lower LVEF, and larger LV end-systolic volume.

Read more in Public Library of Science (PLOS)

PLOS ONE is an international, peer-reviewed, open-access, online publication.

Mol Pharmacol. 2013 Jun 18

Hot Topics: CTGF-mediated regulation of GRK5 affects β-adrenergic receptor responsiveness

CTGF attenuates β-adrenergic receptor responsiveness and cardiotoxicity by induction of Grk5 in cardiomyocytes.
Read more in Molecular Pharmacology

Br J Pharmacol. 2013 Jun 28

Hot Topics: SERCA2 activity is involved in the CNP-mediated functional responses in failing myocardium

CNP-mediated phospholamban- and TnI-phosphorylation by protein kinase G in concert mediate both a predictable CNP-induced lusitropic responses and a less expected negative inotropic response in failing rat hearts

Read more in British Journal of Pharmacology

Eur J Clin Pharmacol. 2013 Jun 7

Hot Topics: Spironolactone does not improve survival in CHF patients on ACE/ARB + beta-blocker treatment

In 4,832 CHF outpatients, no association between the use of spironolactone and improved survival was found when administered in addition to a combination of ACE/ARB and beta-blockers.

Read more in European Journal of Clinical Pharmacology

International Journal of Cardiology, February 2013

Hot Topics: CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload

CTGF attenuates cardiac hypertrophy induced by abdominal aortic banding due to inhibition of signaling mechanisms that promote pathologic myocardial hypertrophy.
Read more in International Journal of Cardiology

Cardiovasc Res (2013)

Hot Topics: NLRP3 is up-regulated in cardiac fibroblasts and mediates myocardial ischemia-reperfusion injury

NLRP3 inflammasome is up-regulated in myocardial fibroblasts after experimental MI, and may be a significant contributor to infarct size development during ischemia-reperfusion. Read more in Cardiovascular Research

European Heart Journal May 7 2013

Hot Topics: Potential harmful effects of oxygen must be considered in myocardial infarction

A systematic literature review that explores the basic and clinical data on the function of oxygen in ischemic heart disease suggest that there are conflicting data on the effects of oxygen treatment, questioning the current guidelines and recommendations and emphasize the need for large clinical trials. Read more in European Heart Journal

Journal of Molecular and Cellular Cardiology, Volume 54, January 2013

Hot Topics: Syndecan-4 is important for the differentiation of cardiac fibroblasts into myofibroblasts in response to mechanical stress

Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in the pressure-overloaded mice.
Read more in Journal of Molecular and Cellular Cardiology


Hot Topics: Levosimendan improves contractility in patients with post-ischaemic myocardium

Levosimendan improved contractility in patients with PCI-treated STEMI with post-ischaemic myocardium complicated by HF (LEAF trial). Read more in Eur J Heart Fail


Hot Topics: Myocardial collagen VIII may function as a "sealant" binding collagen fibrils together

Reduction of collagen VIII following pressure overload may contribute to LV dilatation and development of HF. Read more in Matrix Biology


Hot Topics: Carnitine regulation is disturbed in HF

Increased plasma levels of palmitoyl-carnitine, which play a critical role in fatty acid transport into the mitochondria, in HF are associated with poor prognosis. Read more in Int J Cardiol


Hot Topics: Calcium channel blockers are more effective for heart rate reduction than beta blockers in permanent atrial fibrillation

When comparing the calcium channel blockers diltiazem and verapamil and the beta blockers metoprolol and carvedilol, diltiazem was the most effective drug for reducing the heart rate in patients with permanent AF. Arrhythmia-related symptoms were reduced by treatment with the calcium channel blockers, but not by the beta blockers. Read more in the American Journal of Cardiology.


Hot Topics: High-sensitivity troponin-I concentrations are not closely associated with reversible myocardial ischemia

In patients referred to myocardial perfusion imaging, high-sensitivity troponin-I concentrations were not closely associated with reversible myocardial ischemia, but rather were influenced by variables associated with structural alterations of the myocardium. Read more in Clinical Chemistry.


Hot Topics: Iv. immunoglobulin does not reduce LV remodeling after MI

Intravenous immunoglobulin therapy in patients with myocardial dysfunction after ST elevation MI managed by primary PCI does not affect LV remodeling or function. Read more in Int J Cardiol.


Hot Topics: Several important cytokines and endothrline-1 are induced in alveolar macrophages in patients with heart failure

Several inflammatory factors are known to be increased in the myocardium and in the circulation in heart failure, and this study demonstrate that ET-1, TNFα and IL-6 are increased in alveolar macrophages from heart failure patients and may thus adversely affect the lungs and through secretion also the failing heart. Read more in PLoS One.


Hot Topics: Duration of myocardial early systolic lengthening predicts the presence of significant coronary artery disease

Duration of myocardial early systolic lengthening is prolonged in patients with significant CAD and this might be a useful parameter to identify patients who might benefit from reperfusion therapy. Read more in J Am Coll Cardiol.


Hot Topics: Early-diastolic load, restoring forces, and relaxation rate are independent determinants of peak left ventricular untwisting rate

Early-diastolic load, restoring forces, and relaxation rate are independent determinants of peak left ventricular untwisting rate which is a clinical marker of diastolic function. However, only relaxation rate and restoring forces contributed to untwisting rate during isovolumic relaxation. Read more in Circulation.


Hot Topics: Mitochondrial DNA levels are increased in the circulation after MI

Focal myocardial necrosis due to MI leads to release of circulating mitochondrial DNA which correlates with the degree of myocardial damage and possibly contributes to the non-sterile inflammation seen after MI. Read more in Int J Cardiol.


Hot Topics: Inhibition of cardiac GRK3 attenuates cardiac dysfunction after chronic pressure overload

Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 (GRK3) in mice does not alter the hypertrophic response, but attenuates cardiac dysfunction after chronic pressure overload.

Read more in Am J Physiol Heart Circ Physiol


Hot Topics: Prostanoid-mediated inotropic responses are attenuated in failing myocardium

Prostanoids mediate a sustained positive inotropic response in non-failing human and rat ventricular myocardium and this response appears to be down-regulated in failing hearts.

Read more in Eur J Pharmacol

cover Eur Heart J

Hot Topics: Galectin-3 predicts response to statin therapy

Patients with heart failure of ischemic etiology included in the CORONA trial with galectin-3 values <19.0 ng/mL had a lower primary event rate (cardiovascular death, myocardial infarction, or stroke), lower total mortality, and lower event rate of all-cause mortality and HF hospitalizations after rosuvastatin treatment compared with placebo.

Read more in Eur Heart J


Hot Topics: Compensatory cardiac remodelling after SERCA2 KO

Ablation of SERCA is associated with dramatic sarcoplasmic reticulum volume loss and collapse. Proliferation of longitudinal t-tubules containing Na/Ca-exchangers facilitates plasmalemmal Ca flux, which can trigger release through ryanodine receptors proximal to myofilaments to compensate for the declining sarcoplasmic reticulum function.

Read more in PNAS...

cover Eur Heart J

Hot Topics: A novel clinical method for quantification of regional LV pressure-strain loop area

An echocardiographic method for regional LV pressure-strain loop area corresponds well with invasive measurements and with directly measured myocardial work and it reflects myocardial metabolism.

Read more in Eur Heart J...


Hot Topics: Syndecan-4 is essential for compensatory hypertrophy

Syndecan-4 is essential for development of concentric myocardial hypertrophy in the pressure overloaded heart via stretch-induced activation of the calcineurin-NFAT pathway. Read more here...


Hot Topics: Cardiac troponin-T levels increase during exercise testing

cTnT levels increase during exercise stress testing in patients without evidence of reversible ischemia. However, although cTnT levels were higher at baseline in patients with reversible myocardial ischemia there was no further increase during exercise stress testing. Read more here...


Hot Topics:Agents increasing cGMP amplify 5-HT(4)-elicited positive inotropic response in failing hearts

Cyclic GMP from different sources is functionally compartmented, giving differential regulation of different G(s)-coupled receptors in failing myocardium.
Read more here...


Hot Topics: Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload

In pressure overload in mice, inhibition of SMAD2 signaling prevents downregulation of SERCA2 and attenuates cardiomyocyte hypertrophy and preserves cardiac function.
Read more here...


Hot Topics: Possible link between disturbed fatty acid composition and the progression of heart failure

In patients with heart failure, low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality.
Read more here...

Prize long

Hot Topics: Poster prize winners 9th Annual CHFR Symposium

Linn Elisabeth Fosshaug: Krill oil attenuates left ventricular dilatation and hypertrophy after myocardial infarction in rats
Anton Baysa: The role of p66Shc adaptor protein in postinfarction cardiac remodeling
William E. Louch: Causes and consequences of cardiomyocyte Na+ loading following SERCA2 knockout
Caroline Bull Melsom: The role of inhibitory G protein upon beta-adrenoceptor-mediated signalling and inotropic responses in normal and failing rat heart left ventricle: Functional evidence of “tonic” Gi activation
Trine Baur Opstad The influence of tissue factor and tissue factor pathway inhibitor polymorphisms on thrombin generation in stable CAD patients


Hot Topics: NT-proBNP levels after STEMI are associated with long-term EF and infarct size

NT-proBNP levels at 3 months are more strongly associated with long-term MRI-determined EF and infarct size in STEMI patients than NT-pro BNP levels after 3 days.



Hot Topics: Cardiac troponin T levels predict response to CRT

Baseline highly sensitive troponin T levels <15 ng/L predicts response to CRT and is associated with a more favorable outcome in patients with moderate to severe heart failure.



Hot Topics: CXCL13 signaling through CXCR5 is critical for survival after pressure overload

Lack of the CXCL13 receptor CXCR5 leads to LV dilatation and increased mortality during pressure overload in mice by regulating proteoglycans essential for correct collagen assembly.



Hot Topics: Balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content critical for Ca2+ wave probability

Ca2+ wave development following β-adrenergic stimulation is potentiated in cardiomyocytes with reduced SERCA2 abundance, possible by a CaMKII-dependent shift in the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content.



Hot Topics: Potentially beneficial effects of activin A after MI

Activin A levels are associated with abnormal glucose regulation in patients with MI and may protect against inflammation, hyperglycemia, and oxidative stress.



Hot Topics: Right ventricular mechanical dispersion may be helpful in risk stratification in ARVC

Right ventricular mechanical dispersion evaluated by echocardiography and myocardial strain analysis predicts malignant arrhythmias in patients with ARVC.

Read more here...


Hot Topics: The L-arginine-asymmetric dimethylarginine ratio is strongly related to the severity of chronic heart failure

L-arginine-asymmetric dimethylarginine ratio is associated with 6-minute walking distance, exercise capacity, and inversely with NT-proBNP in patients with chronic heart failure.



Hot Topics: Cardioprotective effects of CTGF after ischemia/reperfusion injury

Transgenic mice with cardiac-restricted overexpression of CTGF and isolated hearts perfused with recombinant hCTGF subjected to ischemia/reperfusion injury displayed markedly diminished infarct size.



Hot Topics: Elevated serum OPG levels predict final infarct size

High levels of circulating osteoprotegerin (OPG) measured the first morning after a PCI-treated acute STEMI are strongly associated with final infarct size.



Hot Topics: Cardiac troponin T in the population is associated with structural heart disease and risk for mortality

Cardiac troponin T levels in the population measured by a new highly sensitive assay is associated with LV hypertrophy and systolic dysfunction and independently associated with all-cause mortality.

Read more in JAMA


Hot Topics: Cardioprotective effects of gene therapy with HIF-1α in skeletal muscle

HIF-1α gene delivery to skeletal muscle preceding myocardial ischemia in mice reduces infarct size and postischemic remodeling and improves cardiac function and vascularization.

Read more in Life Sciences...


Hot Topics: Similar effects of surface and core cooling after cardiac arrest

Therapeutic hypothermia achieved by either surface or intravascular core cooling of out-of-hospital cardiac arrest patients resulted in similar survival to hospital discharge and comparable neurologic function at follow-up.
Read more in Critical Care Medicine


Hot Topics: Muscarinic constitutive inhibition of adenylyl cyclase does not contribute to the reduced β-AR-mediated inotropic effects in failing myocardium

Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i) -dependent constitutive inhibition of myocardial adenylyl cyclase in rats with HF.
Read more in the British Journal of Pharmacology


Hot Topics: Left ventricular thrombus formation is a frequent finding after anterior wall STEMI despite PCI and dual antiplatelet therapy

Left ventricular thrombus formation was detected in 15% of patients with anterior wall STEMI treated acutely with PCI and dual antiplatelet therapy and patients with large infarcts and low ejection fraction were most likely to have thrombi.
Read abstract here...


Hot Topics: Transmural mechanical dispersion is present in symptomatic LQTS mutation carriers

Myocardial contraction duration assessed by strain echocardiography demonstrates longer contraction duration in symptomatic long-QT syndrome (LQTS) mutation carriers in the subendocardium than in the midmyocardium, indicating transmural mechanical dispersion, and this phenomenon was not present in asymptomatic and healthy individuals.
Read abstract here...

Prize long

Hot Topics: Poster prize winners 8th Annual CHFR Symposium

Øystein Sandanger: Identification and characterization of the NLRP3 inflammasome in cardiac fibroblasts. Abstract.
Ida Gjervold Lunde: The z-disc protein syndecan-4 activates pro-hypertrophic calcineurin-NFAT signaling in the myocardium. Abstract.
Fredrik Swift: T-tubule proliferation facilitates trans-sarcolemmal Ca2+ flux to compensate for declining SR function in Serca2 KO mice. Abstract.
Kristina Hermann Haugaa: Mechanical dispersion and ventricular dysfunction by myocardial strain is related to malignant arrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy. Abstract.
Ragnhild Røysland: Prognostic value of osteoprotegerin in chronic heart failure: the GISSI-HF trial. Abstract.

cover Eur Heart J

Hot Topics: Relief of LV pressure overload changes collagen isoform constitution

Relief of pressure overload and reverse LV remodeling in mice alters ECM genes with changes in collagen isoform constitution.

Bjørnstad JL, Sjaastad I, Nygård S, Hasic A, Ahmed MS, Attramadal H, Finsen AV, Christensen G and Tønnessen T.
Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload. Eur Heart J 2010 Jun 5.

cover Eur J Echocardiogr

Hot Topics: Echocardiography, SPECT, and MRI measure EF closely similar after STEMI

Data from NORDISTEMI demonstrate that standard echocardiography, contrast echocardiography, SPECT and MRI measure EF closely similar after STEMI.

Mistry N, Halvorsen S, Hoffmann P, Muller C, Bohmer E, Kjeldsen SE and Bjørnerheim R.
Assessment of left ventricular function with magnetic resonance imaging vs. echocardiography, contrast echocardiography, and single-photon emission computed tomography in patients with recent ST-elevation myocardial infarction. Eur J Echocardiogr 2010 Jun 2.


Hot Topics: Chromogranin B is a putative cardiac biomarker in heart failure

Chromogranin B production is increased in proportion to disease severity in the left ventricle and circulation during heart failure development.

Read paper here...

Hot Topics: ECG early after primary PCI predicts final infarct size and cardiac function

Three methods for calculating ST-segment recovery in ECG at baseline and 90 minutes after PCI predict final infarct size and cardiac function in STEMI patients.

Read more here...

Hot Topics: Myocardial strain parameter predicts arrhythmias after MI

Mechanical dispersion is a strong and independent predictor of arrhythmias requiring ICD therapy after MI.

Read more here...

Hot Topics: Reduced SERCA2 abundance decreases the propensity for Ca wave development in ventricular myocytes

Knockout of SERCA2 in mice resulted in decreased amplitude and decay rate of Ca2+ transients, reduced SR Ca2+ content, and decreased propensity for Ca2+ wave development.

Read more here...

Hot Topics: Everolimus beneficial after heart and lung transplantation

Introduction of everolimus with simultaneous reduction in calcineurin inhibitor exposure in heart and lung transplantation recipients significantly improves renal function.

Read more here...

Hot Topics: Echocardiographic parameters of LV systolic function are excellent parameters to identify NSTEMI patients who may benefit from urgent reperfusion therapy

Global longitudinal strain and wall motion score index measured early in NSTEMI patients predict final infarct size and may therefore be excellent parameters to identify patients with substantial MI who may benefit from urgent reperfusion therapy.

Read more here...

Hot Topics: Natriuretic peptides increase β1-adrenoceptor signaling in failing hearts through phosphodiesterase 3 inhibition

This response may in the long term be detrimental to the failing heart through mechanisms similar to those operating during treatment with phosphodiesterase 3 inhibitors or during chronic β-adrenergic stimulation. Read more here...

Hot Topics: No improvement of long-term survival after iv. drug administration during advanced cardiac life support

Iv. drug administration during advanced cardiac life support following out-of-hospital cardiac arrest improves short-term survival but not survival to hospital discharge or long-term survival. Read more here...

Hot Topics: A highly sensitive troponin T assay gives valuable information in CAD patients

Cardiac troponin T concentrations as measured with a highly sensitive assay are significantly associated with the incidence of cardiovascular death and heart failure in patients with stable coronary artery disease. Read more here...

Hot Topics: Beneficial effects of immediate transfer for PCI after thrombolysis

The NORDISTEMI study demonstrates that immediate transfer for PCI is superior to ischemia-guided management after thrombolysis in patients with STEMI in areas with very long transfer distances.
Read abstract here...

Hot Topics: Intra-aortic balloon counterpulsation stabilizes end-stage heart failure patients

This retrospective study demonstrates that intra-aortic balloon pump (IABP) treatment stabilizes patients in end-stage heart failure with severe hypoperfusion, and that this treatment is successful in bridging acutely decompensated patients to transplantation. Following IABP and heart transplantation, short- and long-term survival, biochemical and invasive and non-invasive hemodynamic outcomes were similar to those in electively transplanted patients. Read abstract...

Hot Topics: Poster prize winners 7th Annual CHFR Symposium

Congratulations to:

Ida G. Lunde
Phosphorylation of syndecan-4 regulates myocardial hypertrophy through the calcineurin-NFAT signalling pathway. Abstract
M. Shakil Ahmed/Jørgen Gravning
CCN2/CTGF prevents heart failure and improves survival after myocardial infarction.Abstract
Mathis Stokke
The effect of beta adrenergic stimulation on arrhythmogenic Ca2+ release in ventricular cardiomyocytes with reduced SERCA2 abundance. Abstract
Ole Jakob How
Dobutamine-norepinephrine, but not vasopressin, restores the ventriculoarterial matching in experimental cardiogenic shock Abstract

Hot Topics: Piboserod - new treatment for heart failure

Treatment with the 5-HT4 serotonin receptor antagonist piboserod in patients with heart failure significantly improves left ventricular function.

Myocardial 5-HT4 serotonin receptors are increased and activated in heart failure. In this prospective, double-blind, parallel group trial, patients with heart failure treated with the potent, selective, 5-HT4 serotonin receptor antagonist piboserod for 24 weeks had a significantly increase in EF by 1.7%. There was a trend for greater increase in EF (2.7%) in a subset of patients not on chronic beta-blocker therapy.
European Journal of Heart Failure 2009 11(8):771-778

Hot Topics: Potentiating effect of inflammation and hyperglycemia in cardiovascular risk prediction

In elderly men with high risk of atherosclerosis, IL-18 was a strong predictor of cardiovascular events after 3 years, but only in subjects with the metabolic syndrome. There was an interaction between elevated fasting glucose and IL-18, and a stepwise increase in the predictive power of IL-18 by quartiles of fasting glucose. Elevated fasting glucose also increased the predictive power of IL-6 and CRP. These findings suggest a potentially synergistic effect of inflammation and hyperglycemia in cardiovascular risk prediction.
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Hot Topics: The heart can compensate for loss of the calcium pump (SERCA2)

In the heart, the release of calcium from intracellular stores triggers muscle contraction. Lowered activity of the SERCA2 pump and reduced stores have been thought to cause heart failure. In a new mouse model it was surprising that despite almost complete absence of SERCA2 protein due to destruction of the Serca2 gene, heart function was maintained due to powerful compensatory mechanisms for a considerable length of time. Hence, future heart failure therapy may be directed towards stimulating the inherent capacity of the heart to compensate for loss of SERCA2 function. Read abstract here... Read editorial here...

Hot Topics: Very early oral glucose tolerance test after an acute STEMI has poor reproducibility and should not be recommended

In an observational cohort study of 224 STEMI patients, the prevalence of abnormal glucose regulation measued by an oral glucose tolerance test (OGTT) at three months was 24.9%, reduced from 46.9% when measured in-hospital. The observed reproducibility of the OGTTs performed in-hospital and at follow up was only 54 %. HbA1c, admission plasma glucose and fasting plasma glucose measured in-hospital seem to be useful as early markers of longstanding glucometabolic disturbance. Read more here...

Hot Topics: Chromogranin A is a strong predictor of mortality in patients with acute coronary syndromes

Chromogranin A (CgA), a protein produced throughout the neuroendocrine system, provides strong and independent information regarding long-term mortality and heart failure hospitalizations in patients with acute coronary syndromes, indicating a role for CgA in ACS risk stratification.

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Hot Topics: LIGHT/PAR-2 synergy - a target for atherogenesis therapy?

The interaction between inflammatory cytokines and endothelial cells is a critical step in atherogenesis leading to endothelial dysfunction and inflammation. LIGHT/PAR-2-driven inflammation could be a pathogenic loop in atherogenesis, potentially representing a target for therapy in this disorder.

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Hot Topics: No effect of drug therapy during cardiac arrest

Despite being widely advocated in resuscitation guidelines all over the world, intravenous drugs such as adrenaline/epinephrine, atropine and amiodarone have never been shown to increase long-term survival after cardiac arrest. This is the first randomized controlled trial to evaluate the effects of intravenous drug therapy vs. no drug therapy during cardiac arrest. This work received a Best Abstract Award at the Hot Topics Session during the Resuscitation Science Symposium at the AHA Scientific Sessions 2008.

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Hot Topics: FX06 - protection from reperfusion injury

FX06, a fibrin-derived peptide, may reduce myocardial necrosis associated with successfully reperfused acute ST-segment elevation myocardial infarction (STEMI), according to results from the FX06 In Reperfusion (FIRE) trial. The FIRE trial showed only modest trends in favor of FX06, but could suggest possible protection from reperfusion injury.

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Hot Topics: Fractalkine

Inflammatory processes mediated by cytokines are involved in the pathogenesis of heart failure. This study in mice identifies altered expression of 14 cytokines never previously associated with heart failure. Most pronounced was the up-regulation of fractalkine (CX3CL1) expression. Enhanced amounts of CX3CL1 were also found in human HF, both systemically and within the myocardium. In vitro experiments suggest that CX3CL1 may be involved in myocardial remodeling and reduction of myocardial contractile function. Read more in J Mol Cell Cardiol

Hot Topics: OPG - a new heart failure marker

Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily with pleiotropic effects on bone metabolism, endocrine function and the immune system. Myocardial expression and circulating levels of OPG are increased in heart failure. These studies demonstrate for the first time that (1) OPG levels on admission are predictive of mortality and heart failure development across the spectrum of acute coronary syndromes, and (2) OPG levels are independently and inversely related to left ventricular systolic function in the general population. Read more in J Am Coll Cardiol and Hypertension.

Hot Topics: G protein-coupled receptor kinases

G protein-coupled receptor kinases (GRK) are nodal regulators of myocardial G protein-coupled receptors. This study is the first to investigate the cardiovascular phenotype of endogenous cardiac GRK3, one of four expressed myocardial GRKs. Transgenic mice with a cardiac myocyte targeted inhibition of GRK3 display a hypertensive phenotype, intolerance for increased preload pressures and increased alpha-adrenergic receptor responsiveness.

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Hot Topics: Rosuvastatins

The first statin trial in heart failure patients does not concur with previous statin trials in non-heart failure patients. This study shows that Rosuvastatin does not reduce the primary outcome or the number of deaths from any cause in older patients with systolic heart failure, but do reduce the number of cardiovascular hospitalizations. Rosuvastatin effectively reduced LDL and CRP and was well tolerated in this fragile patient population.

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